Ben Shelton retired from the US Open due to a shoulder injury, ending his run in the third round. Frances Tiafoe also exited early, leaving Taylor Fritz as the last American hope, intensifying the pressure on him.
The US Open never had a Roger Federer and Rafael Nadal meeting but they would hope the newest rivalry in men's tennis - Carlos Alcaraz vs Jannik Sinner - dubbed "Sincaraz" - would fare differently. On the women's side, defending champion Aryna Sabalenka targets her first major this year, with Iga Swiatek and Coco Gauff two of her biggest rivals.